Befunolol
- Product Name
- Befunolol
- CAS No.
- 39552-01-7
- Chemical Name
- Befunolol
- Synonyms
- Befunolol;Befunolol USP/EP/BP;(±)Befunolol,(±) Befunolol;2-acetyl-7-(2-hyroxy-3-isopropylaminopropoxy)benzofuran;2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran;(-)-2-Acetyl-7-[(S)-2-hydroxy-3-isopropylaminopropoxy]benzofuran;(+)-2-Acetyl-7-[(R)-2-hydroxy-3-isopropylaminopropoxy]benzofuran;7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl ketone;ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl;7-[2-Hydroxy-3-(iso-propylamino)propoxy]-2-benzofuranyl methyl ketone
- CBNumber
- CB01116973
- Molecular Formula
- C16H21NO4
- Formula Weight
- 291.34
- MOL File
- 39552-01-7.mol
Befunolol Property
- Melting point:
- 115°
- Boiling point:
- 433.35°C (rough estimate)
- Density
- 1.1049 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly, Heated)
- form
- Solid
- color
- White to Off-White
- CAS DataBase Reference
- 39552-01-7
Safety
- Toxicity
- LD50 in mice: 100-105 mg/kg i.v. (Ito)
N-Bromosuccinimide Price
- Product number
- B131100
- Product name
- Befunolol
- Packaging
- 25mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- API0008647
- Product name
- BEFUNOLOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.71
- Updated
- 2021/12/16
Befunolol Chemical Properties,Usage,Production
Originator
Bentos,Kakenyaku Kako,Japan,1983
Uses
Befunolol is a β-adrenergic blocker with an intrinsic sympathomimetic action. But it can work as a β-adrenergic partial agonist in isolated organs.
Uses
β-Adrenergic blocker used as antiglaucoma agent in ophthalmie solutions
Definition
ChEBI: Befunolol is a member of benzofurans.
Manufacturing Process
To 8.8 g of 2-acetyl-7-hydroxybenzofuran were added 80 ml of epichlorohydrin and 0.2 g of piperidine hydrochloride and the mixture was heated at 105°C for 3 hours. After the reaction, the excess of epichlorohydrin was evaporated and the resultant was distilled under reduced pressure to give 9.3 g of 2-acetyl-7-(2,3-epoxypropoxy)benzofuranhaving a boiling point of 175° to 176°C/0.7 mm Hg. 6 g of the product was dissolved in 30 ml of ethanol and to the solution was added 10 ml of isopropylamine. After refluxing the mixture for 40 minutes, the solvent was evaporated from the reaction mixture. The resulting residue was recrystallized from cyclohexane-acetone to give 6 g of 2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran having a melting point of 115°C.
Therapeutic Function
Beta-adrenergic blocker
Contact allergens
Befunolol was implicated in allergic contact dermatitis due to beta-blocker agents in eye-drops. Crosssensitivity has been described with levobunolol.